India and Russia have had a long-standing security cooperation partnership, with India relying heavily on Russian weapons and equipment for its armed forces. However, Indian Prime Minister Narendra Modi launched the Make in India initiative in 2014 to develop the country’s defense industry and reduce dependence on imports. The war in Ukraine has caused India to accelerate this process and end negotiations or cancel agreements with Russia on several weapon system acquisitions. Indian officials cited Russia’s logistical problems in delivering new systems as the reason for the cancellations. This article examines how the conflict in Ukraine has impacted one of Russia’s key security cooperation partnerships and how India’s defense industry is developing to produce replacements for these systems. The study provides insights into the challenges and opportunities for India to achieve its goal of self-reliance in defense production.